0:01

So, neuroendocrine tumors can be

0:02

functional or non-functional.

0:04

Once they are functional, they are detected

0:06

earlier because of their hormone secretions.

0:08

And if they are non-functional, they are detected

0:10

later because they grow before presenting

0:13

with abdominal pain or other symptoms due

0:15

to the mass effect on the overlying organs.

0:18

Non-functional NETs (Neuroendocrine Tumors) are usually large and necrotic

0:21

when detected and can sometimes mimic SPN (Solid pseudopapillary neoplasm).

0:24

But again, gender and

0:26

location are more important.

0:28

In making a diagnosis, usually, necrosis is mostly

0:30

central and they do not have hemorrhagic content.

0:32

Hemorrhage is more common with SPN.

0:35

Fifty percent of non-functional tumors, once they

0:36

grow and become more than 5 cm in size, have

0:39

the potential to be possibly malignant

0:41

and undergo metastasis when detected.

0:44

And once they are cystic, they

0:46

undergo degeneration and growth, but

0:48

the evident enhancement during the

0:50

arterial phase will still be there.

0:52

In the retained parenchyma, so you can

0:54

differentiate based on those characteristics on

0:57

imaging, but again there are other ways like doing

1:00

tumor markers or urine HIA or chromogranin to

1:04

differentiate whether it is NET or SPN.

NET Summary (Pancreas)

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